Atogepant: Uses, Side Effects & Warnings
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Generic name: atogepant (a toe' je pant)
Drug class: CGRP inhibitors
Dosage form: tablet (10 mg; 30 mg; 60mg)
Availability: Prescription only
Pregnancy & Lactation: Risk data available
Brand names: Qulipta
What is Atogepant?
Atogepant (Qulipta) is a prescription medicine used for the preventive treatment of episodic migraine in adults. Atogepant is CGRP inhibitor (calcitonin gene-related peptide receptor antagonist) that works by blocking a small protein (CGRP) in the body that is involved with migraines and pain.
Atogepant has been shown in clinical trials to reduce the number of monthly migraines, the number of monthly headache days, and decrease the number of days patients had to take other medicines to treat migraines.
Atogepant is a once-a-day tablet that is FDA approved to prevent episodic migraine headaches in adults.
How should I take Atogepant
- Atogepant is a tablet that is taken by mouth (orally).
- Atogepant is taken once daily, around the same time each day, it can be taken with or without food.
- Atogepant is used to prevent migraines. You should take it every day, whether you feel well or have a migraine.
- Take this medicine exactly as directed by your healthcare provider.
- Do not stop taking atogepant without talking to your doctor.
Dosing information
Qulipta brand of atogepant is available as 10 mg, 30 mg, or 60 mg tablets.
The usual adult dose for preventive treatment of migraine is:
- 10 mg, 30 mg, or 60 mg taken orally once daily and can be taken with or without food.
The dose you are prescribed may depend on your kidney function and any other medications you take. See below “What other drugs will affect atogepant?”
What happens if I miss a dose?
If you miss a dose take your tablet as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What happens if I overdose?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at Poison Help. If the victim has collapsed, has trouble breathing, had a seizure, or can't be awakened, immediately call emergency services at 911.
Before Taking
Tell your healthcare provider about all of your medical conditions before you take atogepant, this includes if you:
- have problems with your liver.
- have problems with your kidneys or are on dialysis.
- are planning to become pregnant or are pregnant, as it is not known if this medicine will harm your unborn baby.
- are planning to breastfeed or are breastfeeding as it is not known if this medicine passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby while taking this medicine.
- are allergic to atogepant, or any of the ingredients in atogepant tablets. A list of ingredients in Qulipta brand of atogepant is below.
What should I know about storage and disposal of this medication?
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
What special dietary instructions should I follow?
Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medication.
Atogepant side effects
Common atogepant side effects may include:
- constipation,
- nausea, and
- fatigue.
This is not all of the possible side effects of atogepant. Talk with doctor, pharmacist or health professional for medical advice about side effects. Side effects may be reported to FDA at 1-800-FDA-1088.
See more: Atogepant Side EffectsWhat other drugs will affect Atogepant?
Tell your doctor, pharmacist, or healthcare provider about any other prescription, over-the-counter medicines, vitamins, and nutritional supplements you are taking, planning to take, or if you are stopping or reducing the dose of these products.
Medications and other products may interact with atogepant. Your doctor may need to change the doses of your medications or monitor you carefully for side effects depending on what other products you are taking.
It is very important to tell your healthcare provider of any of these medications:
- ketoconazole or itraconazole
- cyclosporine
- clarithromycin
- rifampin
- carbamazepine
- phenytoin
- St. John’s wort
- efavirenz
- etravirine
This is not a complete list of drug interactions with atogepant. Not all possible interactions are listed here.
What other information should I know?
Keep all appointments with your doctor.
You should keep a headache diary by writing down when you have headaches. Be sure to share this information with your doctor.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
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